Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep775 | Nuclear receptors and Signal transduction | ECE2016

The impact of mycophenolate mofetil on androgen receptor activity in prostate cancer cells 22Rv1

Zenata Ondrej , Dvorak Zdenek , Vrzal Radim

Mycophenolate mofetil (MYC) is widely used in transplant medicine as an immunosuppressant drug to prevent rejection in organ transplantation. In this work we investigated the effect of MYC on the activity of androgen receptor (AR) by employing gene reporter assay (GRA) and PCR in prostate cancer cell line 22Rv1.Slight but significant activation of AR was observed for cells treated with MYC in stably transfected 22Rv1 cells (AIZ-AR). Moreover, significant...